Retatrutide

4578 published test results across 402 vendors · latest: 14 Oct 2026

Top Retatrutide vendors by published results

Computed from publicly published third-party results. How scoring works · every listing is free and un-buyable. Vendors marked Unverified appear for their published results but are left out of the vendor rankings.

Retatrutide (development code LY3437943) is an investigational once-weekly injectable peptide from Eli Lilly: a “triple agonist” that activates the GIP, GLP-1, and glucagon receptors at once. It is not an approved medicine anywhere; it exists in late-stage clinical trials and, separately, in a research-chemical gray market that this index tracks.

How retatrutide works

Most weight-loss peptides in this class hit one receptor (semaglutide) or two (tirzepatide). Retatrutide adds a third, the glucagon receptor, which is believed to raise energy expenditure on top of the appetite-suppression effects of GIP/GLP-1 signaling. That three-receptor profile is why its trial numbers drew so much attention.

What the trials showed

In the phase 2 obesity trial (NEJM, 2023), the 12 mg weekly group averaged a 24.2% weight reduction at 48 weeks. The first phase 3 results (TRIUMPH-1, May 2026) reported −28.3% at 80 weeks on 12 mg (efficacy estimand; −25.0% when everyone randomized is counted), reaching −30.3% at 104 weeks with no plateau observed in an extension for participants with a baseline BMI of 35 or higher (Lilly). Full dose-by-dose data: our retatrutide dosage guide.

Legal status

Not FDA-approved, no legal pharmacy route, and no legal compounded version: the FDA has sent warning letters to companies selling compounded retatrutide. The gray market sells it “for research use only.” Details and vendor-evaluation checks: where to buy retatrutide.

Tested batches and vendors

Working out reconstitution or syringe units? Use the free peptide calculator, then check your batch’s published test result before trusting the label: vials that miss their label claims turn up regularly in Janoshik’s public results database.

Vendor rankings on PeptideCensus are computed only from publicly published third-party lab results; see the vendor index and how scoring works.

Side effects reported in trials

Gastrointestinal events (nausea, vomiting, diarrhea) were the most common adverse events in published trials: dose-related, mostly mild to moderate, and partially mitigated by the lower 2 mg starting dose. Gray-market vials add a second risk layer the trials never had: unverified contents.

Common questions

Is retatrutide approved?

No. It is investigational, in phase 3 trials (the TRIUMPH program). Any approval date you read is speculation.

Is retatrutide a GLP-1?

Partly: it agonizes the GLP-1 receptor plus the GIP and glucagon receptors, which is why it is often called a “triple G” agonist.

How is retatrutide different from tirzepatide?

Tirzepatide hits two receptors (GIP/GLP-1); retatrutide adds glucagon. Trial-reported weight reduction on retatrutide’s top dose exceeded tirzepatide’s published figures, but they have never been compared head-to-head in one trial.

What does retatrutide cost on the research market?

Prices vary several-fold per milligram between vendors; compare price per tested milligram on the vendor index, not per vial.

Is “GLP-3” the same as retatrutide?

Yes. “GLP-3”, “GLP-3 RT”, “reta” and “triple G” are community and vendor labels for retatrutide (LY3437943). There is no GLP-3 receptor; the name refers to its three receptor targets: GIP, GLP-1 and glucagon.

PeptideCensus aggregates publicly published third-party lab results and links every number to its source. Nothing on this page is medical advice; research compounds are not for human use.

Dosing math: use the free peptide calculator to work out reconstitution and syringe units — then check your vial’s published batch result before relying on the label.